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Blockade of the renin-angiotensin system with ACE inhibitors, which inhibit the biosynthesis of angiotensin II from angiotensin I, is widely used in the treatment of hypertension. In rabbits, embryolethality associated with maternal toxicity reduced body weight gain and food consumption was observed at 45 mg kg day about 12 times the maximum recommended human dose MRHD of 80 mg on mg basis. Serum and urine electrolyte determinations are particularly important when the patient experiences excessive vomiting or receives parenteral fluids. When pregnancy is micardis drog nagra recept detected, Micardis tablets should be discontinued as soon as possible.
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